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Title:
The role of benzathine penicillin G in predicting and preventing all-cause acute respiratory disease in military recruits: 1991–2017
Authors:
Jacob D. Ball, Mattia A. Prosperi, Alfonza Brown, Xinguang Chen, Eben Kenah, Yang Yang, Derek A. T. Cummings, Caitlin M. Rivers
Publication:

Epidemiology & Infection

Publisher:
Cambridge University Press
DOI:
https://doi.org/10.1017/S0950268818001838
Availability:
Available on publisher’s site
Date posted:
July 05, 2018
See also:
Introduction:

The adenovirus vaccine and benzathine penicillin G (BPG) have been used by the US military to prevent acute respiratory diseases (ARD) in trainees, though these interventions have had documented manufacturing problems. We fit Poisson regression and random forest models (RF) to 26 years of weekly ARD incidence data to explore the impact of the adenovirus vaccine and BPG prophylaxis on respiratory disease burden. Adenovirus vaccine availability was among the most important predictors of ARD in the RF, while BPG was the ninth most important. BPG was a significant protective factor against ARD (incidence rate ratio (IRR) = 0.68; 95% confidence interval (CI) 0.67–0.70), but less so than either the old or new adenovirus vaccine (IRR = 0.39, 95% CI 0.38–0.39 and IRR = 0.11, 95% CI 0.11–0.11), respectively. These results suggest that BPG is moderately predictive of, and significantly protective against ARD, though to a lesser extent than either the old or new adenovirus vaccine.