Skip Navigation
CHS blue logo square
Home > Our Work > All Publications > 2015


Our publications keep professionals informed on the most important developments and issues in health security and biosecurity.

Find an article or report by keywords:

Find an article or report or see all by area, author, or year:


Gain-of-Function Research and the Relevance to Clinical Practice

Andy Kilianski, Jennifer B. Nuzzo, Kayvon Modjarrad
Date posted:
September 27, 2015
Publication type:

J Infect Dis September 27, 2015

Oxford University Press on behalf of the Infectious Diseases Society of America
See also:

The ongoing moratorium on gain-of-function (GOF) research with highly pathogenic avian influenza and SARS and MERS coronaviruses has drawn attention to the current debate on these research practices and the potential benefits and risks they present. While much of the discussion has been steered by members of the microbiology and policy communities, additional input from medical practitioners will be highly valuable toward developing a broadly inclusive policy that considers the relative value and harm of GOF research. This review attempts to serve as a primer on the topic for the clinical community by providing a historical context for GOF research, summarizing concerns about its risks, and surveying the medical products which it has yielded.



Our Mission

To protect people’s health from epidemics and disasters and ensure that communities are resilient to major challenges.