Skip Navigation
Explore our COVID-19 Resources and Updates
CHS blue logo square
Home > Our Work > All Publications > 2003


Our publications keep professionals working across the public, private, and academic sectors informed on the most important developments and issues in health security and biosecurity.

Find an article or report by keywords:

Find an article or report or see all by area, author, or year:


Smallpox Vaccination: A Review, Part II

Vincent A. Fulginiti, Arthur Papier, J. Michael Lane, John M. Neff, D. A. Henderson
Date posted:
July 15, 2003
Publication type:

Clin Infect Dis 2003;37(2):251-271

Oxford University Press
Available on publisher's website
See also:

Full article as HTML • PDF


Smallpox vaccination of health care workers, military personnel, and some first responders has begun in the United States in 2002–2003 as one aspect of biopreparedness. Full understanding of the spectrum of adverse events and of their cause, frequency, identification, prevention, and treatment is imperative. This article describes known and suspected adverse events occurring after smallpox vaccination. In part I of this series, we reviewed routine use of smallpox vaccine in primary vaccination and revaccination and outlined the normal, expected reactions.

"In part II, we detail specific characteristics, rates of occurrence, pathogenesis, diagnosis, and treatment for adverse events that occur in some individuals after smallpox vaccination. Vaccination is generally safe and effective for prevention of smallpox. Smallpox vaccination can result in adverse reactions in individuals with and without specific, preexisting susceptibilities. Some of these reactions are benign, if frightening in appearance; some are serious but treatable; and a few are rare and serious and can be life-threatening.

Full article as HTML • PDF



Our Mission

To protect people’s health from epidemics and disasters and ensure that communities are resilient to major challenges.