Skip Navigation
Explore our COVID-19 Resources and Updates
CHS blue logo square
 
 
Home > Our Work > All Publications > 2007

Publications

Our publications keep professionals working across the public, private, and academic sectors informed on the most important developments and issues in health security and biosecurity.

Find an article or report by keywords:

 
 
Find an article or report or see all by area, author, or year:

Title:

The Science of Biodefense: RNAi

Authors:
Allison Chamberlain and Gigi Kwik Gronvall
Date posted:
June 01, 2007
Publication type:
Article
Publication:

Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science. 2007;5(2):104-106. 

Publisher:
© Mary Ann Liebert, Inc.
DOI:
10.1089/bsp.2007.0018
Availability:
Available on publisher's website
See also:

Full article as PDF

Introduction:

RNA interference (RNAi) has significant implications for treating emerging diseases and for biodefense. RNAi can be used to target and silence genes, so it can be used to destroy the genes that SARS, influenza, or other viruses need to invade their hosts. RNAi may also prove to be faster than current technologies in helping develop medical countermeasures for new biological threats, whether they result from natural outbreaks or bioterrorism.

However, like many powerful biotechnologies, RNAi is dual-use and may also be attractive to individuals intending to cause harm. This article describes how RNAi works, some of its current clinical applications, how it can be used in developing biodefense countermeasures, and its potential as a dual-use technology. As this powerful technology progresses, it will be important for scientists and policymakers alike to understand both the positive and negative implications RNAi brings to biodefense.

 

 

Our Mission

To protect people’s health from epidemics and disasters and ensure that communities are resilient to major challenges.